Dr. Smith's research interests include the gut as a source of infection in infants. The development of the normal intestinal bacteria or flora is frequently altered in infants that are hospitalized in the newborn period particularly premature infants. This leads to systemic infections and in some cases the development of necrotizing enterocolitis. Necrotizing enterocolitis is particularly dangerous disease which can lead to significant intestinal loss, sepsis, and possible death. Dr. Smith and his team have working to better understand how alteration in the intestinal flora and other factors can be altered to prevent or lessen the severity of necrotizing enterocolitis.

Key publications

Mehall JR, Kite CA, Saltzman DA, Wallett T, Jackson RJ, Smith SD. Prospective study of the incidence and complications of bacterial contamination of enteral feeding in neonates. J Pediatr Surg. 2002 Aug; 37(8):1177-82.

McVay MR, Boneti C, Habib CM, Keller JE, Kokoska ER, Jackson RJ, Smith SD. Formula fortified with live probiotic culture reduces pulmonary and gastrointestinal bacterial colonization and translocation in a newborn animal model. J Pediatr Surg. 2008 Jan; 43(1):25-9.

Bozeman AP, Dassinger MS, Birusingh RJ, Burford JM, Smith SD. An animal model of necrotizing enterocolitis (NEC) in preterm rabbits. Fetal Pediatr Pathol. 2013 Apr;32(2):113-22.

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