Dr. Bolin's research is in maternal determinants of cardiovascular disease in the fetus and offspring. This is an extension of his clinical practice as a pediatric and fetal cardiologist. In particular, Dr. Bolin is studying the role of altered bioenergetics in the etiology of hypertrophic cardiomyopathy following fetal exposure to maternal diabetes mellitus. Tens of thousands of infants of diabetic mothers are born every year in the US. Approximately one-quarter of these children are born with hypertrophic cardiomyopathy, a disease characterized by abnormal thickening of the heart's pumping chambers. Unfortunately, a significant portion of children with hypertrophic cardiomyopathy die in the neonatal period.
The goal of Dr. Bolin’s translational research is to identify ways to target the mitochondrion for therapeutic intervention in infants of diabetic mothers with hypertrophic cardiomyopathy.
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Congenital heart defects are the most common of all birth defects, occurring at a rate of approximately eight cases per 1,000 live births.