Primary care appointments: 501-364-1202
Specialty care appointments: 501-364-4000
Joana M. Mack, MD, is an assistant professor at the University of Arkansas for Medical Sciences practicing at Arkansas Children's Hospital. She is a pediatric hematologist-oncologist and joined the group in 2018 after completing her residency and fellowship training at Arkansas Children's Hospital. She is also the Pediatric Hematology-Oncology Fellowship program director and is actively involved in educating trainees. She is a member of the Vascular Anomalies Center and provides care for these complex patients.
Dr. Mack leads several research studies in the treatment of patients with Vascular Anomalies. She is a member of the Consortium of iNvestigators of Vascular AnomalieS (CaNVAS) and leads a multi-institutional study evaluating the quality of life in patients with vascular malformations.
Dr. Mack is a site co-investigator for the Consortium of iNvestigators of Vascular AnomalieS (CaNVAS), which is a multi-institutional research consortium founded by a group of pediatric hematologists/oncologists and patients advocacy groups to further advance research in vascular anomalies. Dr. Mack's received a Marion B. Lyon Award for conducting her research study "Anticoagulation Effects on Quality of Life in Patients with Slow-Flow Vascular Malformations." Dr. Mack leads this multi-institutional prospective study and now has 9 other institutions where the study is open throughout the United States. She undertook this endeavor just prior to the beginning of the COVID-19 pandemic and has still been able to enroll half of the subject accrual.
Most notably, Dr. Mack has secured approval for an Investigational New Drug Application from the Food and Drug Administration in March 2022 for her Phase II clinical trial using Cobimetinib, a MEK inhibitor, in patients with extracranial arteriovenous malformations (AVM). Due to the infiltrative nature of AVM, normal tissue must be removed along with the malformation and patients are too often left with significant functional impairments, amputations, and the need for extensive reconstructive surgery. In the search for targets for alternative systemic therapies, research has identified underlying somatic mutations in AVM tissue in mitogen-activated protein kinase 1 (MAP2K1), the gene that encodes MAP-extracellular signal-regulated kinase 1 (MEK1). These mutations increase MEK1 activity and have also been found in cancers. MEK1, a protein product of the MAP2K1 gene, is involved in the RAS/MAPK pathway and controls cellular processes and development. Several studies support the potential efficacy of targeted MEK1 inhibition in tumors with MAP2K1 mutations. Given the success of MEK1 inhibition with neoplasms housing these mutations, it is thought that MEK1 inhibitors may have clinical benefits in patients with extracranial AVMs with RAS/MAPK mutations. This trial is the first of its kind in the Midwest and South, giving much-needed access to this population.
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The Continuity Clinic is an extension of the General Pediatric Center providing diagnosis, treatment and/or follow-up of children with general health problems.
The hematology inpatient unit at Arkansas Children’s Hospital in Little Rock, specializes in pediatric cancers and blood disorders.
With a focus on the expert care of pediatric patients with brain tumors, spinal tumors or neurofibromatosis (NF), our young patients have access to neuro-oncology specialists for every aspect care based on their individual needs.
If your child’s condition is difficult to cure or does not respond to traditional therapies, we are ready and prepared to offer new techniques and clinical trials, providing the skill and experience necessary to treat the most complex cases.
If your newborn or young child has been diagnosed with sickle cell disease, you likely have a lot of questions. The good news is, with the right care, many children with sickle cell live long, healthy lives. Arkansas Children's can diagnose, evaluate and treat children who have sickle cell disease.
Arkansas Children’s has the only team of pediatric neuro-oncology specialists in the state dedicated to helping children with brain and spinal cord tumors.
The nationally recognized Level 1 Trauma Center at Arkansas Children’s in Little Rock, Arkansas is the only Pediatric Level 1 Trauma Center in the state of Arkansas.
The infusion department at Arkansas Children’s Northwest offers a wide range of treatments, including treatment for cancer, gastrointestinal disorders, rheumatology concerns, genetic conditions, and more.
When your child is diagnosed with hemophilia or a bleeding disorder, the experts at the Arkansas Center for Bleeding Disorders work with you and your child to create a care plan that keeps your child healthy while living life to the fullest.
The Cancer and Blood Disorders Program at Arkansas Children's provides specialty care for children with blood and bleeding disorders, tumors and many types of cancer. We are the only pediatric cancer treatment program in the state.
The Bone and Soft-tissue Tumor Program at Arkansas Children’s Hospital provides specialty care for children with cancer of the bone, muscle, or connective tissues.
Find the locations of Arkansas Children's emergency departments in Little Rock and Springdale, and read answers to frequently asked questions about your child's care in the ER.
Arkansas Children’s Hospital, in association with Jefferson Regional, is bringing care closer to home for the families of Southeast Arkansas.
The General Pediatric Clinic (GPC) provides diagnosis, treatment and/or follow-up of children with general health problems. We provide preventive medicine, including periodic immunizations, physical examinations, positive newborn screens and child health maintenance.
Our primary care clinics provide services such as well-child visits, immunizations, newborn care, physicals and more. Call us today to schedule an appointment.
Hand, foot and mouth disease is a common, highly contagious viral disease in children 5 or younger.
Learn about how Arkansas Children's treats patients with the disease and how your child can be seen in one of our primary care clinics.
With an uptick in respiratory illnesses, it's important to know the differences between RSV, flu and COVID-19 viruses and when it's time to take your child to a primary care doctor or the emergency room.
Myths about the flu spread almost as quickly as the virus itself. Read about how Dr. Cockerell, a general ACH pediatrician, busted some of the most common ones.